Total Syntheses of Clerodane Diterpenoids—A Review
نویسندگان
چکیده
منابع مشابه
Total syntheses of echinopines.
A concise and scalable synthesis of a cis-fused bicyclo[5.3.0]decane ring system has been developed for the total synthesis of echinopines. The core of the natural products was constructed efficiently through an intramolecular 1,3-dipolar cycloaddition and ring contraction strategy.
متن کاملEnantiospecific total syntheses of(–)-valeranone
Two convenient methodologies have beendescribed for the enantiospecific synthesis of (–)-valeranone 1. The hydrindanone 12, obtained from the readily andabundantly available monoterpene (R)-carvone,has been converted into the ketoaldehyde 16via the alkene 15b. In anotherdirection the lactone 18, obtainedfrom the hydrindanone 12, has beenelaborated into the ketoaldehyde 16employing two methodolo...
متن کاملTotal Syntheses of (+)- and (−)-Peribysin E
A convergent, stereocontrolled route to either antipode of the cell adhesion inhibitor, peribysin E, has been achieved from carvone. Highlights of the synthesis include a Diels-Alder reaction to generate a cis-decalin framework, followed by semipinacol-type ring contraction to secure the stereochemistry of the C7 quaternary center. Potential mechanistic pathways for the critical ring contractio...
متن کاملTotal syntheses of subereamollines A and B.
The first total syntheses of (+)- and (-)-subereamollines A and B are reported. The enantiomeric forms of the natural products were obtained by preparative chiral HPLC separation of the corresponding racemates.
متن کاملTotal syntheses of natural products containing spirocarbocycles.
The structures of natural products from a variety of sources contain spirocycles, two rings that share a common atom. The spiro motif is finding increasing inclusion in drug candidates, and as a structural component in several promising classes of chiral ligands used in asymmetric synthesis. Total syntheses of products containing all-carbon spirocycles feature several common methods of ring clo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2019
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x19843613